SCHEMBL28676533

SCHEMBL28676533

C[Si](C)(C)C#Cc1c(Br)c(F)cc2c1OC[C@H]1CN(C(=O)O)CCN1C2

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KRAS P01116 18/20 0.44
KCNJ1 P48048 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28658840 0.89 KRAS (0.42) KRAS
SCHEMBL29693092 0.88 KRAS (0.41) KRAS
SCHEMBL28651208 0.85 KRAS (0.47) KRAS
SCHEMBL28656532 0.83 KRAS (0.54) KRAS
SCHEMBL28661182 0.82 KRAS (0.41) KRAS
SCHEMBL28661230 0.81 KRAS (0.45) KRAS
SCHEMBL28664304 0.81 KRAS (0.54) KRAS
SCHEMBL28651226 0.81 KRAS (0.48) KRAS
SCHEMBL28664223 0.77 KRAS (0.56) KRAS
SCHEMBL24558153 0.77 KRAS (0.40) KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113508118-B Fused tricyclic compounds useful as anticancer agents 阿斯利康(瑞典)有限公司 2024-07-19 CN disclosed
CN-113508118-A Fused tricyclic compounds useful as anticancer agents 阿斯利康(瑞典)有限公司 2021-10-15 CN disclosed