Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.83 |
| ▸ | BCR | P11274 | 14/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.80 |
| ▸ | EGFR | P00533 | 2/20 | 0.74 |
| ▸ | PRKCA | P17252 | 2/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
| ▸ | BTK | Q06187 | 1/20 | 0.74 |
| ▸ | ITK | Q08881 | 1/20 | 0.74 |
| ▸ | BRAF | P15056 | 1/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.70 |
| ▸ | KIT | P10721 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29366684 | 1.00 | ABL1 (0.83) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL23246300 | 0.90 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL19556857 | 0.89 | ABL1 (1.00) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL13497838 | 0.88 | ABL1 (0.80) | ABL1BCRPDGFRAPDGFRBEGFR | |
| Cyclohexane SCHEMBL5776157 | 0.87 | ABL1 (0.81) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL4905221 | 0.87 | ABL1 (0.81) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL4897200 | 0.86 | PDGFRA (0.88) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL2004455 | 0.86 | PDGFRA (0.91) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL19556647 | 0.86 | ABL1 (0.80) | ABL1BCRPDGFRAPDGFRBEGFR | |
| SCHEMBL6265756 | 0.86 | ABL1 (0.80) | ABL1BCRPDGFRAPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110078706-B | Imatinib derivative and preparation method and application thereof | 浙江师范大学 | 2022-02-01 | — | — | CN | disclosed |