Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.80 |
| ▸ | BCR | P11274 | 14/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.80 |
| ▸ | KIT | P10721 | 3/20 | 0.75 |
| ▸ | PRKCA | P17252 | 3/20 | 0.74 |
| ▸ | EGFR | P00533 | 2/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
| ▸ | BTK | Q06187 | 1/20 | 0.74 |
| ▸ | ITK | Q08881 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897200 | 0.92 | PDGFRA (0.88) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL23246300 | 0.90 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL19556857 | 0.89 | ABL1 (1.00) | ABL1BCRPDGFRAPDGFRBKIT | |
| Cyclohexane SCHEMBL5776157 | 0.87 | ABL1 (0.81) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL11927813 | 0.86 | PDGFRA (1.00) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL2004455 | 0.86 | PDGFRA (0.91) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL29366684 | 0.86 | ABL1 (0.83) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL28677768 | 0.86 | ABL1 (0.83) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL19556647 | 0.86 | ABL1 (0.80) | ABL1BCRPDGFRAPDGFRBKIT | |
| SCHEMBL9782 | 0.85 | PDGFRA (1.00) | ABL1BCRPDGFRAPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005065074-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-07-21 | — | — | WO | claimed |
| WO-2005065074-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-07-21 | — | — | WO | disclosed |