SCHEMBL28678558

SCHEMBL28678558

CC(C)(C)OC(=O)CCOCCc1ccccc1C=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
HPGD P15428 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TLR2 O60603 1/20 0.34
TLR1 Q15399 1/20 0.34
ADRB2 P07550 1/20 0.33
HTR1A P08908 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
CYP4F2 P78329 1/20 0.31
CYP4A11 Q02928 1/20 0.31
STING1 Q86WV6 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GSTO1 P78417 1/20 0.31
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6802449 0.88 CYP4F2 (0.41) ALDH1A1HPGDHTTSMN1; SMN2PTGDR2
SCHEMBL28510004 0.82 TAAR1 (0.38) ALDH1A1HPGDHTTTLR2TLR1
SCHEMBL28672892 0.82 CYP4F2 (0.49) ALDH1A1TLR2TLR1MTNR1AMTNR1B
SCHEMBL28676646 0.81 HTT (0.42) ALDH1A1HPGDHTTTLR2TLR1
SCHEMBL13225857 0.81 MEN1 (0.39) HTTMTNR1AMTNR1BMEN1LMNA
SCHEMBL2366865 0.79 CDYL (0.48) ALDH1A1MTNR1AL3MBTL1KDM4ETDP1
SCHEMBL13225825 0.79 POLB (0.42) LMNA
SCHEMBL28694461 0.78 FFAR1 (0.40) ALDH1A1HPGDSMN1; SMN2KDM4E
SCHEMBL3590948 0.77 TDP1 (0.49) ALDH1A1HTTL3MBTL1MEN1KMT2A
SCHEMBL28874109 0.77 BACE1 (0.35) ALDH1A1TLR2TLR1MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109195975-B Diazaspiro [5.5] undecane derivative and application thereof 四川海思科制药有限公司 2022-01-04 CN disclosed