Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 11/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALPG | P10696 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28669731 | 0.86 | MAPK1 (0.60) | TSHRMAPK1ATMMEN1KMT2A | |
| SCHEMBL21952052 | 0.84 | KMT2A (0.63) | TSHRMAPK1ATMMEN1KMT2A | |
| SCHEMBL28655968 | 0.76 | KMT2A (0.58) | TSHRMAPK1ATMMEN1KMT2A | |
| SCHEMBL28655970 | 0.75 | ALDH1A1 (0.49) | TSHRMAPK1ATMMEN1KMT2A | |
| SCHEMBL28660621 | 0.73 | SMN1; SMN2 (0.58) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL24029052 | 0.73 | MEN1 (0.53) | MAPK1ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL24019625 | 0.73 | MEN1 (0.53) | MAPK1ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL28669425 | 0.73 | HPGD (0.53) | TSHRMAPK1ATMMEN1KMT2A | |
| SCHEMBL24029051 | 0.73 | MEN1 (0.53) | MAPK1ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL28673736 | 0.73 | HPGD (0.53) | TSHRMAPK1ATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |