Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Tryptamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 3/20 | 0.96 |
| ▸ | HTR1B known ✓ | P28222 | 2/20 | 0.96 |
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.59 |
| ▸ | HTR1F known ✓ | P30939 | 1/20 | 0.57 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 9/20 | 0.96 |
| ▸ | HTR2C | P28335 | 4/20 | 0.96 |
| ▸ | HTR6 | P50406 | 4/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.96 |
| ▸ | MPO | P05164 | 2/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.96 |
| ▸ | HTR7 | P34969 | 2/20 | 0.96 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.96 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | CTSK | P43235 | 1/20 | 0.96 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.96 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.93 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptamine SCHEMBL10874156 | 1.00 | HTR2A (0.96) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL29373222 | 0.98 | HTR2A (1.00) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL26725 | 0.98 | HTR2A (1.00) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL8714244 | 0.98 | HTR2A (1.00) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL274183 | 0.96 | PMP22 (1.00) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL28686775 | 0.96 | PMP22 (1.00) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL599675 | 0.96 | HTR2A (0.96) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL22127053 | 0.96 | HTR2A (0.96) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL4936407 | 0.96 | HTR2A (0.96) | HTR2AHTR2CHTR6CYP3A4HTR1D | |
| Tryptamine SCHEMBL9472063 | 0.96 | HTR2A (0.96) | HTR2AHTR2CHTR6CYP3A4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113964273-B | Compound, perovskite thin-film solar cell and preparation method thereof | 义乌协同创新研究院 | 2023-04-07 | — | — | CN | claimed |
| CN-113964273-A | Compound, perovskite thin-film solar cell and preparation method thereof | 义乌协同创新研究院 | 2022-01-21 | — | — | CN | claimed |
| CN-113964273-B | Compound, perovskite thin-film solar cell and preparation method thereof | 义乌协同创新研究院 | 2023-04-07 | — | — | CN | disclosed |
| CN-113964273-A | Compound, perovskite thin-film solar cell and preparation method thereof | 义乌协同创新研究院 | 2022-01-21 | — | — | CN | disclosed |