Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29971642 | 1.00 | RET (0.48) | RETGPR119TSHRALOX15OPRD1 | |
| SCHEMBL20137436 | 0.87 | RET (0.51) | RETTSHROPRD1CYP3A4CYP2D6 | |
| SCHEMBL20137435 | 0.87 | RET (0.51) | RETTSHROPRD1CYP3A4CYP2D6 | |
| SCHEMBL20147950 | 0.86 | RET (0.50) | RETTSHRALOX15CYP2D6HSD17B10 | |
| SCHEMBL20069627 | 0.85 | RET (0.52) | RETTSHRALOX15CYP2D6HSD17B10 | |
| SCHEMBL25502428 | 0.84 | RET (0.51) | RETTSHRALOX15CYP3A4CYP2D6 | |
| SCHEMBL20137489 | 0.83 | RET (0.47) | RETGPR119OPRD1OPRK1JAK2 | |
| SCHEMBL20148111 | 0.80 | RET (0.47) | RETTSHRALOX15CYP2D6HSD17B10 | |
| SCHEMBL28664449 | 0.79 | BACE1 (0.45) | RETGPR119TSHRALOX15CNR2 | |
| SCHEMBL29970883 | 0.79 | BACE1 (0.45) | RETGPR119TSHRALOX15CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |