Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 6/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29970883 | 1.00 | BACE1 (0.45) | BACE1RETGPR119MDM2MDM4 | |
| SCHEMBL20137466 | 0.90 | RET (0.39) | RETMDM4TP53 | |
| SCHEMBL20137467 | 0.90 | RET (0.39) | RETMDM4TP53 | |
| SCHEMBL20069388 | 0.84 | TLR2 (0.39) | RETMDM4TP53 | |
| Trifluoroacetic Acid SCHEMBL29971166 | 0.81 | TLR2 (0.38) | MDM2MDM4TP53 | |
| SCHEMBL28679088 | 0.79 | RET (0.48) | RETGPR119ALOX15TSHRCNR2 | |
| SCHEMBL29971642 | 0.79 | RET (0.48) | RETGPR119ALOX15TSHRCNR2 | |
| SCHEMBL2950721 | 0.77 | BACE1 (0.48) | BACE1GPR119ALOX15TSHRCNR2 | |
| SCHEMBL20069294 | 0.77 | CASP3 (0.45) | RET | |
| SCHEMBL20069292 | 0.77 | CASP3 (0.45) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |