SCHEMBL28679155

SCHEMBL28679155

O=c1c2ccccc2nc2cc(Cl)ccn12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.64
KDM4E B2RXH2 6/20 0.64
GAA P10253 3/20 0.64
ALDH1A1 P00352 3/20 0.64
GLA P06280 2/20 0.64
PARP1 P09874 1/20 0.53
LMNA P02545 2/20 0.48
HTT P42858 2/20 0.48
APAF1 O14727 1/20 0.47
IDO1 P14902 1/20 0.47
TDO2 P48775 1/20 0.47
IDO2 Q6ZQW0 1/20 0.47
MAPK1 P28482 1/20 0.47
HSD17B10 Q99714 3/20 0.45
HPGD P15428 2/20 0.45
CYP1A1 P04798 1/20 0.45
CYP1A2 P05177 1/20 0.45
KEAP1 Q14145 1/20 0.45
CYP1B1 Q16678 1/20 0.45
CASP1 P29466 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22059444 0.81 KDM4E (0.64) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL11759583 0.81 KDM4E (0.64) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL18015436 0.81 KDM4E (0.64) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL19933619 0.81 KDM4E (0.52) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL11240930 0.79 KDM4E (0.60) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL2427657 0.78 KDM4E (1.00) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL19794416 0.78 KDM4E (0.59) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL11758101 0.78 KDM4E (0.59) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL28659594 0.77 KDM4E (0.67) SMN1; SMN2KDM4EGAAALDH1A1GLA
SCHEMBL28355495 0.77 KDM4E (0.67) SMN1; SMN2KDM4EGAAALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110252351-B Application of copper catalyst in catalyzing reaction of 1-pyridyl indole compound and tert-butyl nitrite 苏州大学 2021-12-10 CN disclosed