Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 16/20 | 0.39 |
| ▸ | CCND1 | P24385 | 16/20 | 0.39 |
| ▸ | CCND3 | P30281 | 13/20 | 0.39 |
| ▸ | CCND2 | P30279 | 9/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28382215 | 0.87 | CDK4 (0.40) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL22553578 | 0.82 | CDK4 (0.43) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL22553579 | 0.82 | CDK4 (0.43) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4826130 | 0.81 | CDK4 (0.52) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL29507845 | 0.81 | CDK4 (0.52) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL22557912 | 0.81 | CDK4 (0.44) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL22553544 | 0.78 | PIK3CA (0.43) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL22553522 | 0.77 | CDK4 (0.41) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL22557914 | 0.77 | CDK4 (0.41) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL28677140 | 0.75 | PIK3CA (0.49) | CDK4CCND1CCND3CCND2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007697-A | Antiproliferative agents for the treatment of PAH | 辉瑞公司 | 2022-02-01 | — | — | CN | disclosed |