Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 5/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 3/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210223 | 0.91 | CTSK (0.34) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL212117 | 0.91 | CTSK (0.35) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL2840212 | 0.90 | P2RX4 (0.33) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL8510311 | 0.90 | P2RX4 (0.34) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL213060 | 0.89 | CTSK (0.35) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL212975 | 0.89 | P2RX4 (0.33) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL2840024 | 0.89 | P2RX4 (0.33) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL209633 | 0.89 | ABL1 (0.34) | P2RX4ABL1ANO1CTSA | |
| SCHEMBL212607 | 0.89 | CTSK (0.35) | P2RX4NOTUMCTSKABL1TDP1 | |
| SCHEMBL209966 | 0.89 | CTSK (0.34) | P2RX4NOTUMCTSKABL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |