Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 8/20 | 0.51 |
| ▸ | CDK4 | P11802 | 5/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CCND3 | P30281 | 2/20 | 0.50 |
| ▸ | CCND1 | P24385 | 2/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CCND2 | P30279 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28714701 | 0.84 | CDK4 (0.62) | CSF1RCDK2KCNH2CDK4CDK6 | |
| SCHEMBL24664303 | 0.83 | CSF1R (0.63) | CSF1RCDK2KCNH2EGFRCDK4 | |
| SCHEMBL28717945 | 0.82 | HDAC6 (0.75) | CSF1RCDK2KCNH2CDK4CDK6 | |
| SCHEMBL28687755 | 0.82 | CDK4 (0.69) | CSF1RCDK2EGFRCDK4CDK6 | |
| SCHEMBL29370753 | 0.82 | CDK4 (0.69) | CSF1RCDK2EGFRCDK4CDK6 | |
| SCHEMBL28676599 | 0.82 | CDK2 (0.57) | CDK2EGFRCDK4CDK1CCNA2 | |
| SCHEMBL29368374 | 0.81 | CDK4 (0.68) | CSF1RCDK2EGFRCDK4CDK6 | |
| SCHEMBL28689771 | 0.81 | CDK4 (0.68) | CSF1RCDK2EGFRCDK4CDK6 | |
| SCHEMBL24664372 | 0.76 | CSF1R (0.55) | CSF1RCDK2KCNH2CDK4CDK6 | |
| SCHEMBL28987265 | 0.73 | CDK4 (0.63) | CSF1RCDK2KCNH2EGFRCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | claimed |
| CN-113999210-A | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-02-01 | — | — | CN | claimed |
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | disclosed |
| CN-113999210-A | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-02-01 | — | — | CN | disclosed |