Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 6/20 | 0.45 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28717945 | 0.91 | HDAC6 (0.75) | CDK4HDAC6CDK2KCNH2JAK2 | |
| SCHEMBL28717954 | 0.86 | JAK2 (0.50) | CDK4HDAC6CDK2JAK2FLT3 | |
| SCHEMBL28716656 | 0.86 | CDK4 (0.83) | CDK4HDAC6CDK2JAK2CSF1R | |
| SCHEMBL28714810 | 0.84 | JAK2 (0.48) | CDK4HDAC6CDK2KCNH2JAK2 | |
| SCHEMBL28679677 | 0.84 | CSF1R (0.58) | CDK4HDAC6CDK2KCNH2CSF1R | |
| SCHEMBL28714820 | 0.78 | CDK4 (0.75) | CDK4HDAC6CDK2KCNH2JAK2 | |
| SCHEMBL28721352 | 0.77 | HDAC1 (0.60) | CDK4HDAC6CDK2JAK2HDAC1 | |
| SCHEMBL28701859 | 0.77 | HDAC6 (1.00) | CDK4HDAC6JAK2HDAC1SYK | |
| SCHEMBL28701854 | 0.76 | HDAC6 (0.99) | CDK4HDAC6JAK2HDAC1SYK | |
| SCHEMBL28717950 | 0.76 | HDAC1 (0.53) | CDK4HDAC6JAK2HDAC1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114105958-B | Hydroximic acid-containing 2-phenylamino pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-11-22 | — | — | CN | disclosed |
| CN-114105958-A | Hydroximic acid-containing 2-phenylamino pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-03-01 | — | — | CN | disclosed |