Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28679732 | 0.90 | JAK3 (0.38) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL28687000 | 0.89 | JAK3 (0.49) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL28672841 | 0.89 | FGFR1 (0.41) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL28673136 | 0.88 | JAK3 (0.49) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL21486164 | 0.86 | JAK3 (0.61) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL20699364 | 0.81 | JAK3 (0.63) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL20699361 | 0.81 | JAK3 (0.63) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL30161777 | 0.81 | JAK3 (0.63) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL20699415 | 0.79 | JAK3 (0.64) | JAK3PIK3CDPIM1GSK3BPIK3CA | |
| SCHEMBL20699367 | 0.79 | PIK3CD (0.47) | JAK3PIK3CDPIM1GSK3BPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113831326-A | Condensed heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2021-12-24 | — | — | CN | disclosed |