Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.49 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | JAK1 | P23458 | 7/20 | 0.45 |
| ▸ | TYK2 | P29597 | 7/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28672841 | 0.91 | FGFR1 (0.41) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL28680409 | 0.88 | JAK3 (0.45) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL28679732 | 0.85 | JAK3 (0.38) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL28687000 | 0.81 | JAK3 (0.49) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL28931797 | 0.81 | JAK3 (0.51) | JAK3JAK2JAK1TYK2FGFR1 | |
| Trifluoroacetic Acid SCHEMBL28686997 | 0.80 | JAK3 (0.47) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL21486164 | 0.74 | JAK3 (0.61) | JAK3 | |
| SCHEMBL29003379 | 0.72 | JAK3 (0.42) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL28689643 | 0.72 | FGFR1 (0.48) | JAK3JAK2JAK1TYK2FGFR1 | |
| SCHEMBL20699364 | 0.70 | JAK3 (0.63) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113831326-A | Condensed heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2021-12-24 | — | — | CN | disclosed |