SCHEMBL28680922

SCHEMBL28680922

CNc1cccc(CC(NC(=O)OC(C)(C)C)C(=O)O)c1

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACE P12821 2/20 0.63
CTSS P25774 6/20 0.55
CTSK P43235 5/20 0.55
CTSB P07858 4/20 0.55
PPARA Q07869 3/20 0.55
PPARG P37231 2/20 0.55
CTSL P07711 2/20 0.54
ITGB3 P05106 2/20 0.52
ITGA2B P08514 2/20 0.52
ITGB1 P05556 1/20 0.52
ITGAV P06756 1/20 0.52
ITGB5 P18084 1/20 0.52
PTPN1 P18031 1/20 0.52
APP P05067 1/20 0.48
MAPK1 P28482 1/20 0.48
KLK5 Q9Y337 1/20 0.47
PPARD Q03181 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9956406 0.90 ACE (0.63) ACECTSSCTSKCTSBPPARA
SCHEMBL9956403 0.90 ACE (0.63) ACECTSSCTSKCTSBPPARA
SCHEMBL9955383 0.88 ACE (0.60) ACECTSSCTSKCTSBPPARA
SCHEMBL9955380 0.88 ACE (0.60) ACECTSSCTSKCTSBPPARA
SCHEMBL29145384 0.88 ACE (0.60) ACECTSSCTSKCTSBPPARA
SCHEMBL6157428 0.86 ACE (0.51) ACECTSSCTSKCTSBPPARA
SCHEMBL14638965 0.85 ACE (0.63) ACECTSSCTSKCTSBPPARA
SCHEMBL2729283 0.85 ACE (0.57) ACECTSSCTSKCTSBPPARA
SCHEMBL8422101 0.85 ACE (0.57) ACECTSSCTSKCTSBPPARA
SCHEMBL8422097 0.85 ACE (0.57) ACECTSSCTSKCTSBPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113943259-A Amino acid derivative, preparation method and application thereof 西安禾渼生物医药有限公司 2022-01-18 CN disclosed