Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 13/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | CLK3 | P49761 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30290451 | 1.00 | MAP4K1 (0.57) | MAP4K1DYRK1ACLK1CHEK1ALK | |
| SCHEMBL30290452 | 0.97 | MAP4K1 (0.59) | MAP4K1DYRK1ACLK1CHEK1ALK | |
| SCHEMBL28668303 | 0.97 | MAP4K1 (0.59) | MAP4K1DYRK1ACLK1CHEK1ALK | |
| SCHEMBL28674874 | 0.89 | MAP4K1 (0.71) | MAP4K1CHEK1ALKLCKMAP4K3 | |
| SCHEMBL30290640 | 0.89 | MAP4K1 (0.71) | MAP4K1CHEK1ALKLCKMAP4K3 | |
| SCHEMBL28667479 | 0.88 | MAP4K1 (0.57) | MAP4K1CHEK1LCKMAP4K3ACHE | |
| SCHEMBL30290485 | 0.86 | MAP4K1 (0.64) | MAP4K1CHEK1ALKLCKMAP4K3 | |
| SCHEMBL28680971 | 0.86 | MAP4K1 (0.64) | MAP4K1CHEK1ALKLCKMAP4K3 | |
| SCHEMBL28682310 | 0.85 | MAP4K1 (0.59) | MAP4K1CHEK1LCKMAP4K3ACHE | |
| SCHEMBL28687884 | 0.84 | MAP4K1 (0.67) | MAP4K1CHEK1LCKMAP4K3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861188-A | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2021-12-31 | — | — | CN | disclosed |