Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | MELK | Q14680 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30290485 | 1.00 | MAP4K1 (0.64) | MAP4K1ALKCHEK1MELKJAK2 | |
| SCHEMBL30290640 | 0.94 | MAP4K1 (0.71) | MAP4K1ALKCHEK1MELKACVR1 | |
| SCHEMBL28674874 | 0.94 | MAP4K1 (0.71) | MAP4K1ALKCHEK1MELKACVR1 | |
| SCHEMBL28693364 | 0.88 | MAP4K1 (0.57) | MAP4K1CHEK1LCKMAP4K3 | |
| SCHEMBL30290489 | 0.88 | MAP4K1 (0.54) | MAP4K1CHEK1LCKMAP4K3 | |
| SCHEMBL28693837 | 0.88 | MAP4K1 (0.54) | MAP4K1CHEK1LCKMAP4K3 | |
| SCHEMBL30290736 | 0.88 | MAP4K1 (0.65) | MAP4K1ALKLCKMAP4K3 | |
| SCHEMBL28682310 | 0.86 | MAP4K1 (0.59) | MAP4K1CHEK1JAK2LCKMAP4K3 | |
| SCHEMBL28666223 | 0.86 | MAP4K1 (0.71) | MAP4K1ALKCHEK1LCKMAP4K3 | |
| SCHEMBL28680967 | 0.86 | MAP4K1 (0.57) | MAP4K1ALKCHEK1LCKMAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861188-A | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2021-12-31 | — | — | CN | disclosed |