Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | CDK7 | P50613 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28681436 | 0.94 | STAT3 (0.61) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28695985 | 0.92 | STAT3 (0.55) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28673399 | 0.91 | MEN1 (0.58) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28699068 | 0.91 | STAT3 (0.54) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28673422 | 0.91 | MEN1 (0.59) | CYP3A4L3MBTL1STAT3ALDH1A1KDM4E | |
| SCHEMBL28699093 | 0.90 | CTDSP1 (0.62) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28679409 | 0.89 | STAT3 (0.54) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28672562 | 0.89 | CHEK1 (0.60) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28683197 | 0.88 | STAT3 (0.51) | CHEK1AURKADAPK3PRKD3PAK4 | |
| SCHEMBL28698376 | 0.87 | POLB (0.61) | CHEK1AURKADAPK3PRKD3PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113747920-A | Immune checkpoint inhibitor combination therapy using quinoline carboxamide derivatives | 株式会社益力多本社 | 2021-12-03 | — | — | CN | disclosed |
| CN-112703001-A | Combination cancer therapy using quinoline carboxamide derivatives | 株式会社益力多本社 | 2021-04-23 | — | — | CN | disclosed |