Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 9/20 | 0.64 |
| ▸ | LHCGR | P22888 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965949 | 1.00 | TRPM8 (0.64) | TRPM8LHCGROPRK1TMEM97SIGMAR1 | |
| SCHEMBL4062479 | 0.85 | TRPM8 (0.86) | TRPM8LHCGROPRK1TMEM97SIGMAR1 | |
| SCHEMBL4067787 | 0.84 | TRPM8 (0.58) | TRPM8LHCGROPRK1TMEM97SIGMAR1 | |
| SCHEMBL3960182 | 0.82 | TRPM8 (0.78) | TRPM8LHCGROPRK1TMEM97SIGMAR1 | |
| SCHEMBL30965947 | 0.79 | TRPM8 (0.61) | TRPM8KCNH2TRPV1CHRM3 | |
| SCHEMBL22776026 | 0.79 | TRPM8 (0.61) | TRPM8KCNH2TRPV1CHRM3 | |
| SCHEMBL22776130 | 0.79 | TRPM8 (0.61) | TRPM8KCNH2TRPV1CHRM3 | |
| SCHEMBL22776267 | 0.79 | TRPM8 (0.61) | TRPM8KCNH2TRPV1CHRM3 | |
| SCHEMBL30965919 | 0.79 | TRPM8 (0.61) | TRPM8KCNH2TRPV1CHRM3 | |
| SCHEMBL29561050 | 0.79 | TRPM8 (0.61) | TRPM8KCNH2TRPV1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950477-B | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113950477-A | Modulators of progranulin and methods of use thereof | 阿库达医疗公司 | 2022-01-18 | — | — | CN | disclosed |