Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 9/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 8/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686143 | 1.00 | NTRK1 (0.58) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28684857 | 0.92 | NTRK1 (0.64) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28684861 | 0.92 | NTRK1 (0.64) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL29387722 | 0.91 | NTRK1 (0.54) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28698706 | 0.91 | NTRK1 (0.54) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28698708 | 0.91 | NTRK1 (0.54) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL29387760 | 0.90 | NTRK1 (0.64) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28706600 | 0.90 | NTRK1 (0.53) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28684921 | 0.89 | NTRK1 (0.55) | NTRK1NTRK2NTRK3CHEK1KDR | |
| SCHEMBL28684924 | 0.89 | NTRK1 (0.55) | NTRK1NTRK2NTRK3CHEK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4056558-A1 | INDAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF | Jinan University (CN) | 2022-09-14 | — | — | EP | disclosed |
| US-20220281821-A1 | INDAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS | JINAN UNIVERSITY (CN) | 2022-09-08 | — | — | US | disclosed |
| CN-114072387-A | Indazole compound and medicinal composition and application thereof | 暨南大学 | 2022-02-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220281821-A1 | INDAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS | TNK2, TNNI3K, CSNK1G3 | NTRK1 63/4885NTRK2 162/4885NTRK3 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.