Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28706635 | 1.00 | NOTUM (0.48) | NOTUMPTPN1TSHRALDH1A1IRAK4 | |
| SCHEMBL29627833 | 0.99 | NOTUM (0.49) | NOTUMPTPN1TSHRALDH1A1IRAK4 | |
| SCHEMBL29749785 | 0.99 | NOTUM (0.49) | NOTUMPTPN1TSHRALDH1A1IRAK4 | |
| SCHEMBL28686167 | 0.91 | NOTUM (0.55) | NOTUMPTPN1TSHRALDH1A1IRAK4 | |
| SCHEMBL28697278 | 0.91 | NOTUM (0.55) | NOTUMPTPN1TSHRALDH1A1IRAK4 | |
| SCHEMBL28698733 | 0.86 | TSHR (0.47) | NOTUMTSHRALDH1A1LMNAGAA | |
| SCHEMBL29627823 | 0.84 | TSHR (0.49) | NOTUMTSHRALDH1A1LMNAGAA | |
| SCHEMBL28691758 | 0.83 | NOTUM (0.49) | NOTUMPTPN1TSHRALDH1A1LMNA | |
| SCHEMBL29627850 | 0.82 | NOTUM (0.50) | NOTUMPTPN1TSHRALDH1A1LMNA | |
| SCHEMBL2409298 | 0.81 | TSHR (0.52) | NOTUMPTPN1TSHRALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072405-A | Heterocyclic monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2022-02-18 | — | — | CN | disclosed |