SCHEMBL28686276

SCHEMBL28686276

N#Cc1ccc(Oc2cccc(C=O)c2)cc1C#N

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.54
MAOB P27338 6/20 0.47
MAOA P21397 5/20 0.47
ALDH1A1 P00352 3/20 0.45
HPGD P15428 2/20 0.45
AR P10275 3/20 0.44
SRC P12931 1/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
NPSR1 Q6W5P4 1/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
PDE4B Q07343 1/20 0.41
ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30185052 1.00 CYP19A1 (0.54) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL25285812 0.85 CYP19A1 (0.50) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL29965252 0.85 CYP19A1 (0.50) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL31168160 0.83 CYP19A1 (0.67) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL5145150 0.83 CYP19A1 (0.67) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL1374021 0.83 CYP19A1 (0.67) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL4104432 0.83 CYP19A1 (0.47) CYP19A1MAOBMAOAALDH1A1SRC
SCHEMBL13908822 0.81 CYP19A1 (0.65) CYP19A1MAOBMAOAALDH1A1HPGD
SCHEMBL6856729 0.81 SRC (0.56) MAOBMAOAALDH1A1SRCMEN1
SCHEMBL30631693 0.81 SRC (0.60) MAOBMAOAALDH1A1HPGDSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113817166-B Acid-base co-fusion based imidazole dinitrile resin and preparation method thereof 四川大学 2023-01-17 CN disclosed
CN-113817166-A Acid-base co-fusion based imidazole dinitrile resin and preparation method thereof 四川大学 2021-12-21 CN disclosed