SCHEMBL29965252

SCHEMBL29965252

N#Cc1ccc(Oc2ccc(C=O)cc2)cc1C#N

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.50
ALDH1A1 P00352 4/20 0.48
HPGD P15428 2/20 0.48
PARP10 Q53GL7 1/20 0.45
PARP3 Q9Y6F1 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
AR P10275 3/20 0.44
PDE4B Q07343 1/20 0.43
ESRRA P11474 2/20 0.43
MAOB P27338 3/20 0.43
MAOA P21397 2/20 0.43
KDM4E B2RXH2 2/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CYP2A6 P11509 1/20 0.41
ALDH1A3 P47895 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25285812 1.00 CYP19A1 (0.50) CYP19A1ALDH1A1HPGDPARP10PARP3
SCHEMBL8551880 0.87 AR (0.53) CYP19A1ALDH1A1PARP10PARP3AR
SCHEMBL30185052 0.85 CYP19A1 (0.54) CYP19A1ALDH1A1HPGDNPSR1AR
SCHEMBL28686276 0.85 CYP19A1 (0.54) CYP19A1ALDH1A1HPGDNPSR1AR
SCHEMBL20934585 0.85 PARP10 (0.45) CYP19A1ALDH1A1HPGDPARP10PARP3
SCHEMBL4809997 0.85 SLC22A12 (0.47) ALDH1A1PARP10PARP3ARESRRA
SCHEMBL3696845 0.85 AR (0.51) ALDH1A1PARP10PARP3ARESRRA
SCHEMBL1377229 0.85 CYP19A1 (0.62) CYP19A1ALDH1A1HPGDNPSR1AR
SCHEMBL9472016 0.85 CYP19A1 (0.62) CYP19A1ALDH1A1HPGDNPSR1AR
SCHEMBL4581525 0.83 CYP19A1 (0.65) CYP19A1ALDH1A1HPGDNPSR1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117820377-A Cyclotriphosphazene derivative flame retardant containing phthalonitrile structure and preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2024-04-05 CN disclosed
CN-115368276-B Novel bisphthalonitrile compound and application thereof 北京化工大学 2024-02-02 CN disclosed
CN-115368563-B Solvent-free method for preparing aldimine bond-containing bisphthalonitrile compound, polymer and application thereof 北京化工大学 2023-12-15 CN disclosed
CN-116332982-A Liquid processable diphthalic nitrile monomers and resins 劳斯莱斯有限公司 2023-06-27 CN disclosed
CN-113817166-B Acid-base co-fusion based imidazole dinitrile resin and preparation method thereof 四川大学 2023-01-17 CN disclosed
CN-115368563-A Solvent-free method for preparing bis-phthalonitrile compound containing aldimine bond, polymer and application thereof 北京化工大学 2022-11-22 CN disclosed
CN-115368276-A Novel bisphthalonitrile compound and application thereof 北京化工大学 2022-11-22 CN disclosed