SCHEMBL28686407

SCHEMBL28686407

Nc1c(N)c2c3ccccc3ccc2c2ccc3ccccc3c12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 3/20 0.55
HSD17B10 Q99714 7/20 0.52
ALDH1A1 P00352 6/20 0.52
TSHR P16473 3/20 0.52
TDP1 Q9NUW8 3/20 0.52
CYP2A6 P11509 1/20 0.52
HPGD P15428 5/20 0.50
CYP3A4 P08684 3/20 0.50
CYP1A2 P05177 2/20 0.50
HIF1A Q16665 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ATM Q13315 2/20 0.50
CASP1 P29466 2/20 0.50
CASP7 P55210 2/20 0.50
MAPK1 P28482 2/20 0.50
RAB9A P51151 1/20 0.50
THRB P10828 1/20 0.50
KEAP1 Q14145 1/20 0.48
MAOA P21397 2/20 0.45
ACHE P22303 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22142550 0.93 HPRT1 (0.54) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL22653085 0.86 HPRT1 (0.50) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL29517920 0.84 HPRT1 (0.67) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL4847084 0.84 HPRT1 (0.67) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL18600599 0.83 HSD17B10 (0.50) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL297902 0.81 HPRT1 (0.72) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL4847322 0.81 HSD17B10 (0.65) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL29697319 0.81 HPRT1 (0.72) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL30583321 0.81 HPRT1 (0.72) HPRT1HSD17B10ALDH1A1TSHRTDP1
SCHEMBL30892665 0.81 HPRT1 (0.72) HPRT1HSD17B10ALDH1A1TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114031564-A 13, 14-picene quinoxaline and 13, 14-picene diazole derivatives and preparation method thereof 华东师范大学 2022-02-11 CN claimed
CN-114031564-A 13, 14-picene quinoxaline and 13, 14-picene diazole derivatives and preparation method thereof 华东师范大学 2022-02-11 CN disclosed
CN-114031564-A 13, 14-picene quinoxaline and 13, 14-picene diazole derivatives and preparation method thereof 华东师范大学 2022-02-11 CN disclosed