Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912868 | 0.83 | ACHE (0.42) | MC4RMEN1KMT2AESR1ESR2 | |
| SCHEMBL29883093 | 0.83 | ACHE (0.42) | MC4RMEN1KMT2AESR1ESR2 | |
| SCHEMBL28693977 | 0.81 | ESR1 (0.40) | MC4RMEN1KMT2AESR1ESR2 | |
| SCHEMBL28689000 | 0.77 | ESR1 (0.39) | MC4RMEN1KMT2AKDM4EESR1 | |
| SCHEMBL28671430 | 0.74 | PRMT5 (0.46) | ACHE | |
| SCHEMBL29883371 | 0.74 | PRMT5 (0.46) | ACHE | |
| SCHEMBL2109285 | 0.73 | CYP1A2 (0.39) | MC4RMEN1KMT2AKDM4EESR1 | |
| SCHEMBL29883119 | 0.71 | KMT2A (0.63) | MEN1KMT2AKDM4ESIGMAR1NPC1 | |
| SCHEMBL1038680 | 0.71 | KMT2A (0.63) | MEN1KMT2AKDM4ESIGMAR1NPC1 | |
| SCHEMBL2110977 | 0.71 | CYP1A2 (0.45) | MC4RMEN1KMT2ASIGMAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113880866-B | Aza-tetrahydronaphthyridine compound, preparation method thereof, pharmaceutical composition and application thereof | 上海维申医药有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-113880866-A | Aza-tetrahydronaphthyridine compound, preparation method thereof, pharmaceutical composition and application thereof | 上海维申医药有限公司 | 2022-01-04 | — | — | CN | disclosed |