Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.37 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28574122 | 0.94 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| SCHEMBL28688365 | 0.85 | KDM4E (0.32) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| SCHEMBL28610733 | 0.82 | EGLN1 (0.42) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| SCHEMBL28921629 | 0.82 | MAPT (0.40) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| SCHEMBL28578997 | 0.80 | KDM4E (0.33) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL28109358 | 0.79 | KDM4E (0.48) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL29009070 | 0.75 | KDM4E (0.58) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Tributyrin SCHEMBL27551720 | 0.73 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28130110 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL30466185 | 0.73 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114133285-A | Efficient multifunctional water-soluble fertilizer and preparation method thereof | 戴斌 | 2022-03-04 | — | — | CN | claimed |
| CN-114133282-A | Preparation method of efficient magnesium polyphosphate fertilizer | 谭宏伟 | 2022-03-04 | — | — | CN | claimed |
| CN-214863545-U | Reaction device for synthesizing succinic acid bis-diethylaminoethanol ester citrate | 河南省科学院高新技术研究中心 | 2021-11-26 | — | — | CN | claimed |
| CN-114133285-A | Efficient multifunctional water-soluble fertilizer and preparation method thereof | 戴斌 | 2022-03-04 | — | — | CN | disclosed |
| CN-114133282-A | Preparation method of efficient magnesium polyphosphate fertilizer | 谭宏伟 | 2022-03-04 | — | — | CN | disclosed |
| CN-214863545-U | Reaction device for synthesizing succinic acid bis-diethylaminoethanol ester citrate | 河南省科学院高新技术研究中心 | 2021-11-26 | — | — | CN | disclosed |