SCHEMBL28690252

SCHEMBL28690252

CN1CCN(C2CCCc3cc(C(=O)O)ccc32)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 3/20 0.47
ALDH1A1 P00352 2/20 0.45
DRD3 P35462 2/20 0.44
HTR1A P08908 1/20 0.44
MTNR1B P49286 2/20 0.44
CTSS P25774 2/20 0.42
TSHR P16473 1/20 0.41
KDM4E B2RXH2 2/20 0.40
MAPT P10636 1/20 0.40
ABL1 P00519 2/20 0.40
PDGFRB P09619 2/20 0.40
KIT P10721 2/20 0.40
TDP1 Q9NUW8 1/20 0.39
L3MBTL3 Q96JM7 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
POLB P06746 1/20 0.39
GAA P10253 1/20 0.39
NR4A1 P22736 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CHRNA7 P36544 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29404649 1.00 HTR2C (0.47) HTR2CALDH1A1DRD3HTR1AMTNR1B
SCHEMBL2576042 0.92 ABL1 (0.44) HTR2CALDH1A1DRD3MTNR1BABL1
SCHEMBL2575580 0.92 ABL1 (0.44) HTR2CALDH1A1DRD3MTNR1BABL1
SCHEMBL2573895 0.92 ABL1 (0.44) HTR2CALDH1A1DRD3MTNR1BABL1
Hydrochloric Acid SCHEMBL28064938 0.91 ABL1 (0.44) HTR2CALDH1A1DRD3MTNR1BABL1
Hydrochloric Acid SCHEMBL28064738 0.91 ABL1 (0.44) HTR2CALDH1A1DRD3MTNR1BABL1
SCHEMBL6404873 0.90 MTNR1B (0.52) HTR2CALDH1A1DRD3HTR1AMTNR1B
SCHEMBL29407143 0.88 KDM4E (0.48) HTR2CALDH1A1DRD3HTR1AMTNR1B
SCHEMBL28686740 0.86 MTNR1B (0.47) HTR2CALDH1A1DRD3HTR1AMTNR1B
SCHEMBL29407150 0.86 MTNR1B (0.47) HTR2CALDH1A1DRD3HTR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114105908-A Preparation method of key intermediate of tetrahydronaphthalene benzamide 辽宁大学 2022-03-01 CN disclosed