Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.56 |
| ▸ | CDK1 | P06493 | 6/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.56 |
| ▸ | CDK9 | P50750 | 4/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA4 | P22748 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA6 | P23280 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29368259 | 1.00 | CDK2 (0.56) | CDK2CDK1CCNE1CCNB2CCNB1 | |
| SCHEMBL29368330 | 0.83 | IKBKB (0.54) | CDK2CDK1CCNE1CCNB1CDK9 | |
| SCHEMBL28674245 | 0.83 | IKBKB (0.54) | CDK2CDK1CCNE1CCNB1CDK9 | |
| SCHEMBL28687755 | 0.80 | CDK4 (0.69) | CDK2CDK1CCNE1CCNB2CCNB1 | |
| SCHEMBL29370753 | 0.80 | CDK4 (0.69) | CDK2CDK1CCNE1CCNB2CCNB1 | |
| SCHEMBL28689771 | 0.80 | CDK4 (0.68) | CDK2CDK1CCNE1CCNB2CCNB1 | |
| SCHEMBL29368374 | 0.80 | CDK4 (0.68) | CDK2CDK1CCNE1CCNB2CCNB1 | |
| SCHEMBL28676987 | 0.79 | CDK4 (0.54) | CDK2CDK4HDAC6AURKAAURKB | |
| SCHEMBL28676601 | 0.79 | CDK4 (0.53) | CDK2CDK4HDAC6AURKAAURKB | |
| SCHEMBL28716652 | 0.72 | HDAC6 (0.42) | CDK4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | claimed |
| CN-113999210-A | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-02-01 | — | — | CN | claimed |
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | disclosed |
| CN-113999210-A | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-02-01 | — | — | CN | disclosed |