Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 18/20 | 0.67 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.67 |
| ▸ | PHGDH | O43175 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28692145 | 0.87 | PTGER4 (0.74) | PTGER4PTGER2 | |
| SCHEMBL24861880 | 0.86 | PTGER4 (0.72) | PTGER4PTGER2PHGDH | |
| SCHEMBL26417331 | 0.86 | PTGER4 (0.72) | PTGER4PTGER2PHGDH | |
| SCHEMBL26417308 | 0.83 | PTGER4 (0.73) | PTGER4PTGER2PHGDH | |
| SCHEMBL24861881 | 0.83 | PTGER4 (0.73) | PTGER4PTGER2PHGDH | |
| Palupiprant SCHEMBL881413 | 0.81 | PTGER4 (1.00) | PTGER4PTGER2 | |
| Palupiprant SCHEMBL881212 | 0.81 | PTGER4 (1.00) | PTGER4PTGER2 | |
| Palupiprant SCHEMBL20563735 | 0.81 | PTGER4 (1.00) | PTGER4PTGER2 | |
| Palupiprant SCHEMBL29517740 | 0.81 | PTGER4 (1.00) | PTGER4PTGER2 | |
| SCHEMBL10122170 | 0.80 | PTGER4 (0.81) | PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354585-A | Synthesis of novel EP4 antagonists and their use in cancer and inflammation | 湖北生物医药产业技术研究院有限公司 | 2021-09-07 | — | — | CN | disclosed |