Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13569652 | 1.00 | SIGMAR1 (0.44) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 | |
| SCHEMBL30194981 | 0.92 | SIGMAR1 (0.49) | SIGMAR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL27427346 | 0.92 | SIGMAR1 (0.49) | SIGMAR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL19212453 | 0.92 | SIGMAR1 (0.49) | SIGMAR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL25339310 | 0.91 | SMN1; SMN2 (0.48) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 | |
| SCHEMBL6071087 | 0.91 | SMN1; SMN2 (0.48) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 | |
| SCHEMBL32671859 | 0.91 | SMN1; SMN2 (0.48) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 | |
| SCHEMBL13963235 | 0.91 | SMN1; SMN2 (0.48) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 | |
| SCHEMBL13963237 | 0.91 | SMN1; SMN2 (0.48) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 | |
| SCHEMBL13963234 | 0.91 | SMN1; SMN2 (0.48) | SIGMAR1SMN1; SMN2NPC1RAB9APDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023059605-A1 | HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE | HALDA THERAPEUTICS OPCO, INC. (US) | 2023-04-13 | — | — | WO | disclosed |
| EP-3414252-B1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO HEALTH INC (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |