Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.56 |
| ▸ | JAK1 | P23458 | 17/20 | 0.56 |
| ▸ | TYK2 | P29597 | 5/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29488743 | 1.00 | JAK2 (0.56) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL29488719 | 0.93 | JAK2 (0.55) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL28695877 | 0.93 | JAK2 (0.55) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL22801365 | 0.88 | IRAK4 (0.64) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL23495087 | 0.85 | JAK2 (0.62) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL30273461 | 0.81 | JAK2 (0.58) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL20560479 | 0.81 | JAK2 (0.58) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29648482 | 0.81 | JAK2 (0.61) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL23495066 | 0.81 | JAK2 (0.61) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL23495050 | 0.81 | JAK2 (0.61) | JAK2JAK1TYK2JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109970743-B | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds as JAK inhibitors | 豪夫迈·罗氏有限公司 | 2022-03-04 | — | — | CN | disclosed |