Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.61 |
| ▸ | JAK1 | P23458 | 20/20 | 0.61 |
| ▸ | TYK2 | P29597 | 6/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495066 | 1.00 | JAK2 (0.61) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29654154 | 0.92 | JAK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23495070 | 0.92 | JAK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23495092 | 0.91 | JAK2 (0.51) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL23495059 | 0.88 | JAK2 (0.60) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL23495050 | 0.84 | JAK2 (0.61) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL23495076 | 0.82 | JAK2 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29488743 | 0.81 | JAK2 (0.56) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL28695876 | 0.81 | JAK2 (0.56) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL28695877 | 0.80 | JAK2 (0.55) | JAK2JAK1TYK2JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |