E388

E388

SCHEMBL28696

O=C(O)CCSCCC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 1.00
KMT2A Q03164 1/20 1.00
HSD17B10 Q99714 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
TSHR P16473 3/20 0.69
ALKBH5 Q6P6C2 1/20 0.53
SUCNR1 Q9BXA5 1/20 0.53
EGLN1 Q9GZT9 1/20 0.53
CYP2C19 P33261 1/20 0.52
BHMT Q93088 3/20 0.50
CYP1A2 P05177 1/20 0.48
SLC22A6 Q4U2R8 1/20 0.47
NFKB1 P19838 1/20 0.44
PMP22 Q01453 1/20 0.44
CYP2D6 P10635 1/20 0.44
HIF1A Q16665 1/20 0.44
APEX1 P27695 1/20 0.42
FFAR3 O14843 1/20 0.42
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E388 SCHEMBL28962323 1.00 LMNA (1.00) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL10963526 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL21494504 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL5169308 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL5170829 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL4194910 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL11415832 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL341724 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL9715431 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR
E388 SCHEMBL9715444 0.97 LMNA (0.93) LMNAKMT2AHSD17B10TDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 28083 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026104829-A2 USES AND COMPOSITIONS INNOSPEC LIMITED (GB) 2026-05-21 WO claimed
WO-2026104841-A1 ESTER COMPOUNDS INNOSPEC LIMITED (GB) 2026-05-21 WO claimed
WO-2026107218-A1 SEMICONDUCTOR-BASED PHOTOCATALYSTS FOR DEHYDROGENATION REACTIONS BASF CORPORATION (US) 2026-05-21 WO claimed
WO-2026104848-A2 USES AND COMPOSITIONS INNOSPEC LIMITED (GB) 2026-05-21 WO claimed
CN-122060973-A Quenching oil special for 05Cr15Ni5Cu4Nb precipitation hardening stainless steel and preparation method and application thereof 季华实验室 2026-05-19 CN claimed
CN-122037594-A Polymethyl methacrylate nanoparticle compounded Pickering emulsified asphalt and preparation method thereof 太原理工大学 2026-05-15 CN claimed
CN-117142991-B Method for preparing polyol carboxylic acid ester, polymerizable composition and adhesive 益丰新材料股份有限公司 2026-05-12 CN claimed
CN-122011999-A Environment-friendly sealing glue for water supply network threading connector and preparation process thereof 中交广州航道局有限公司 2026-05-12 CN claimed
WO-2026087745-A1 AN ANTIOXIDANT COMPOSITION COMPRISING A CINNAMIC ACID DERIVATIVE BRAIN Biotech AG (DE) 2026-04-30 WO claimed
EP-4732825-A1 AN ANTIOXIDANT COMPOSITION COMPRISING A CINNAMIC ACID DERIVATIVE BRAIN Biotech AG (DE) 2026-04-29 EP claimed
US-4043942-A Modified nickel catalyst systems and their use in reductive alkylation reactions THE GOODYEAR TIRE & RUBBER COMPANY (US) 1977-08-23 US claimed
US-4039631-A FLUOROPOLYMERS, DIALLYL TEREPHTHALATE AND ISOPHTHALATE ALLIED CHEMICAL CORPORATION (US) 1977-08-02 US claimed
US-4028332-A HOMO- AND COPOLYMERS OF ETHYLENE, DIALKYL PENTAERYTHRITOL DIPHOSPHITE, THIODIPROPIONIC ACID ESTERS, AND ACETYLENIC DIPEROXY COMPOUNDS PHILLIPS PETROLEUM COMPANY (US) 1977-06-07 US claimed
US-4017467-A POLYTHIOL PHILLIPS PETROLEUM COMPANY (US) 1977-04-12 US claimed
US-4015990-A TOCOPHEROL DERIVATIVE AS STABILIZER MITSUBISHI PAPER MILLS, LTD. (JA) 1977-04-05 US claimed
US-3996194-A STABILIZERS UNIROYAL INC. (US) 1976-12-07 US claimed
US-3959220-A Polymer additives comprising transition metal complexes with trivalent phosphorous compounds CINCINNATI MILACRON CHEMICALS, INC. (US) 1976-05-25 US claimed
US-3951911-A Stabilized propylene-based polymer compositions DART INDUSTRIES INC. (US) 1976-04-20 US claimed
US-3947525-A ETHYLENE-CHLOROTRIFLUOROETHYLENE COPOLYMER ALLIED CHEMICAL CORPORATION (US) 1976-03-30 US claimed
US-3931078-A SEALANT AND COATING COMPOSITIONS FROM POLY(OXYALKYLENE)-POLYESTER-POLY(MONOSULFIDE)-POLYTHIOLS, COAL TAR, AND FILLERS PHILLIPS PETROLEUM COMPANY (US) 1976-01-06 US claimed