Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 7/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988084 | 0.83 | PDK4 (0.48) | PDK4TNFGRM5GRM1HTR6 | |
| SCHEMBL28698221 | 0.83 | NAMPT (0.52) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL28698477 | 0.81 | BACE1 (0.47) | GRM5KEAP1NFE2L2ABCB1 | |
| SCHEMBL28679621 | 0.81 | BTK (0.37) | BTKKEAP1NFE2L2 | |
| SCHEMBL29707442 | 0.80 | PDK4 (0.49) | PDK4TNFGRM5GRM1HTR6 | |
| SCHEMBL22957460 | 0.80 | PDK4 (0.49) | PDK4TNFGRM5GRM1HTR6 | |
| SCHEMBL7030868 | 0.78 | NAMPT (0.49) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL31640404 | 0.77 | PDK4 (0.52) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL15639859 | 0.76 | PDK4 (0.52) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL20660583 | 0.75 | MEN1 (0.45) | PDK4GRM5GRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-B1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO HEALTH INC (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |