Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.55 |
| ▸ | SKP1 | P63208 | 2/20 | 0.55 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30725763 | 1.00 | CKS1B (0.55) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL28690986 | 0.85 | CKS1B (0.59) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL30725791 | 0.85 | CKS1B (0.59) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL30725778 | 0.84 | CKS1B (0.57) | CKS1BSKP1SKP2CNR1MAPT | |
| SCHEMBL30725764 | 0.84 | CKS1B (0.57) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL28691774 | 0.84 | CKS1B (0.57) | CKS1BSKP1SKP2CNR1MAPT | |
| SCHEMBL28691799 | 0.84 | CKS1B (0.57) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL30725777 | 0.82 | CKS1B (0.55) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL30725783 | 0.82 | CNR1 (0.62) | CKS1BSKP1SKP2CYP19A1CNR1 | |
| SCHEMBL28707155 | 0.82 | CNR1 (0.62) | CKS1BSKP1SKP2CYP19A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206499-A | 2,3, 5-Trisubstituted pyrazine compound and preparation method and application thereof | 郑州大学 | 2024-06-18 | — | — | CN | disclosed |
| CN-118146165-A | 2,3, 5-Trisubstituted pyrazine compound and preparation method and application thereof | 郑州大学 | 2024-06-07 | — | — | CN | disclosed |
| CN-113968824-B | 2,3, 5-trisubstituted pyrazine compound and preparation method and application thereof | 郑州大学 | 2024-01-19 | — | — | CN | disclosed |
| CN-113968824-A | 2,3, 5-trisubstituted pyrazine compound and preparation method and application thereof | 郑州大学 | 2022-01-25 | — | — | CN | disclosed |