Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 10/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087527 | 0.84 | SMN1; SMN2 (0.40) | MAPK8MAPK9MAPK10PRKD3MAP4K4 | |
| SCHEMBL22002746 | 0.70 | ABL1 (0.40) | MAPK8MAPK9MAPK10MAPK1PIK3CA | |
| SCHEMBL11052863 | 0.69 | SAE1 (0.63) | MAPK8MAPK9MAPK10MAPK1PIK3CA | |
| SCHEMBL2088565 | 0.68 | L3MBTL1 (0.44) | NOS3NOS1 | |
| SCHEMBL13753679 | 0.68 | KMT2A (0.66) | MAPK1ABL1 | |
| SCHEMBL6623293 | 0.67 | CXCR2 (0.48) | MAPK8MAPK9MAPK10MAPK1PIK3CA | |
| SCHEMBL6068126 | 0.66 | DYRK1A (0.71) | PIK3CAABL1 | |
| SCHEMBL19493884 | 0.64 | MAPK8 (0.38) | MAPK8MAPK9MAPK10MAPK1PIK3CA | |
| SCHEMBL28057063 | 0.64 | HSP90AB1 (0.43) | MAPK8NOS3NOS1NOS2 | |
| SCHEMBL27749254 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227452-A2 | PYRIDINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068468-A2 | PYRIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |