Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828740 | 0.94 | HRH3 (0.48) | HRH3HDAC1PDE7AMAPTKDM4E | |
| SCHEMBL2857095 | 0.90 | ALDH1A1 (0.47) | HRH3HDAC1PDE7AMAPTKDM4E | |
| SCHEMBL2854266 | 0.87 | HRH3 (0.43) | HRH3HDAC1PTPN11PDE7AMAPT | |
| SCHEMBL2868151 | 0.85 | FGFR3 (0.49) | HRH3PTPN11MAPTKDM4ERAB9A | |
| SCHEMBL2829488 | 0.83 | ALDH1A1 (0.52) | HRH3PDE7AMAPTKDM4ERAB9A | |
| SCHEMBL2828172 | 0.81 | HRH3 (0.46) | HRH3HDAC1PDE7AMAPTKDM4E | |
| SCHEMBL2827341 | 0.78 | FGFR3 (0.53) | HRH3MAPTKDM4ERAB9AL3MBTL1 | |
| SCHEMBL2829204 | 0.77 | HRH3 (0.44) | HRH3HDAC1PDE7AMAPTKDM4E | |
| SCHEMBL2824462 | 0.76 | HRH3 (0.51) | HRH3HDAC1PTPN11 | |
| SCHEMBL2825785 | 0.75 | KDM4E (0.48) | HRH3HDAC1PTPN11MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | disclosed |