Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.58 |
| ▸ | FLT3 | P36888 | 16/20 | 0.58 |
| ▸ | TYK2 | P29597 | 9/20 | 0.56 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29425676 | 1.00 | JAK2 (0.58) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL29741634 | 0.80 | JAK2 (0.68) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL30595812 | 0.79 | JAK2 (0.47) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL24664327 | 0.79 | JAK2 (0.61) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL29741551 | 0.78 | JAK2 (0.63) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL28685382 | 0.77 | JAK2 (0.57) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL28707631 | 0.77 | JAK2 (0.56) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL29741568 | 0.77 | AXL (0.66) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL28791515 | 0.77 | AXL (0.66) | JAK2FLT3TYK2JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL31460911 | 0.76 | JAK2 (0.69) | JAK2FLT3TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181199-B | 2, 4-disubstituted pyrimidine derivative, preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-114181199-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-03-15 | — | — | CN | disclosed |