SCHEMBL28700306

SCHEMBL28700306

COc1ccc([C@H](C)N[C@H](C#N)c2ccsc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.48
GAA P10253 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.42
ACACB O00763 2/20 0.40
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
ACHE P22303 1/20 0.38
ACP3 P15309 2/20 0.38
LMNA P02545 1/20 0.34
OPRM1 P35372 1/20 0.34
OPRD1 P41143 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28700308 1.00 ALDH1A1 (0.48) ALDH1A1GAASMN1; SMN2ACACBCA1
SCHEMBL28698030 1.00 ALDH1A1 (0.48) ALDH1A1GAASMN1; SMN2ACACBCA1
SCHEMBL28698033 1.00 ALDH1A1 (0.48) ALDH1A1GAASMN1; SMN2ACACBCA1
SCHEMBL28698031 1.00 ALDH1A1 (0.48) ALDH1A1GAASMN1; SMN2ACACBCA1
Hydrochloric Acid SCHEMBL28684221 0.76 ACP3 (0.44) ALDH1A1GAAACACBCA1CA2
Hydrochloric Acid SCHEMBL28684217 0.76 ACP3 (0.44) ALDH1A1GAAACACBCA1CA2
Hydrochloric Acid SCHEMBL28933201 0.76 ACP3 (0.44) ALDH1A1GAAACACBCA1CA2
Hydrochloric Acid SCHEMBL28933200 0.76 ACP3 (0.44) ALDH1A1GAAACACBCA1CA2
SCHEMBL10506713 0.75 ALDH1A1 (0.65) ALDH1A1GAASMN1; SMN2ACACBCA1
Hydrochloric Acid SCHEMBL27231657 0.72 ALDH1A1 (0.60) ALDH1A1GAASMN1; SMN2ACACBCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114075141-B Opioid receptor \"bias\" ligand, preparation method and medical application thereof 上海致根医药科技有限公司 2025-02-25 CN disclosed
CN-114075141-A Opioid receptor 'bias' ligand, preparation method and application thereof in medicine 上海致根医药科技有限公司 2022-02-22 CN disclosed