Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27699317 | 0.86 | TRPV1 (0.51) | TRPV1PPARDRXRARXRBRXRG | |
| SCHEMBL8267587 | 0.84 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL8491910 | 0.83 | KDM4E (0.59) | KDM4ECYP1A2MAPTPTGDR2 | |
| SCHEMBL11246793 | 0.83 | PPARD (0.47) | TRPV1PTGDR2PSEN1PSEN2APH1B | |
| SCHEMBL4197626 | 0.78 | TDP1 (0.61) | TRPV1KDM4ECYP1A2MAPT | |
| SCHEMBL29978735 | 0.78 | TDP1 (0.61) | TRPV1KDM4ECYP1A2MAPT | |
| SCHEMBL10639318 | 0.77 | KDM4E (0.50) | KDM4ECYP1A2MAPTPTGDR2 | |
| Hydrochloric Acid SCHEMBL6201867 | 0.77 | KDM4E (0.59) | TRPV1KDM4ECYP1A2MAPT | |
| SCHEMBL3729702 | 0.76 | PSEN1 (0.57) | PTGDR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27685591 | 0.75 | TRPV1 (0.59) | TRPV1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |