Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255067 | 0.88 | TDO2 (0.50) | PPARDPPARGNR1H2NR1H3TDP1 | |
| SCHEMBL11262804 | 0.86 | TDP1 (0.45) | PTGDR2TDP1 | |
| SCHEMBL11251835 | 0.85 | TDP1 (0.54) | PTGDR2PPARGNR1H2NR1H3TDP1 | |
| SCHEMBL11261678 | 0.83 | TDP1 (0.45) | PTGDR2PPARGNR1H2NR1H3TDP1 | |
| SCHEMBL11246786 | 0.83 | LMNA (0.48) | PTGDR2PPARGNR1H2NR1H3TDP1 | |
| SCHEMBL11255704 | 0.83 | PTGDR2 (0.49) | PTGDR2TDP1 | |
| SCHEMBL2870033 | 0.83 | TRPV1 (0.50) | PPARDPTGDR2PSEN1PSEN2APH1B | |
| SCHEMBL11259158 | 0.80 | TDP1 (0.42) | PTGDR2PPARGNR1H2NR1H3TDP1 | |
| SCHEMBL11258880 | 0.80 | MMP2 (0.51) | PPARDPTGDR2TDP1 | |
| SCHEMBL11250186 | 0.80 | PTGDR2 (0.43) | PTGDR2PPARGNR1H2NR1H3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |