Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940349 | 0.92 | HRH3 (0.48) | HRH3GPR119HPGDEPHX1USP2 | |
| SCHEMBL27162932 | 0.89 | GPR119 (0.43) | HRH3GPR119HPGDEPHX1USP2 | |
| SCHEMBL346048 | 0.87 | GPR119 (0.39) | L3MBTL3L3MBTL1HRH3GPR119CYP1A2 | |
| Hydrochloric Acid SCHEMBL485037 | 0.86 | GPR119 (0.40) | L3MBTL3L3MBTL1HRH3GPR119CYP1A2 | |
| SCHEMBL118654 | 0.85 | CYP1A2 (0.50) | GPR119CYP1A2USP2SMN1; SMN2GABRD | |
| SCHEMBL30135841 | 0.85 | HPGD (0.45) | HRH3GPR119HPGDEPHX1USP2 | |
| Hydrochloric Acid SCHEMBL2075849 | 0.84 | CYP1A2 (0.49) | GPR119CYP1A2USP2SMN1; SMN2GABRD | |
| SCHEMBL485158 | 0.83 | CYP1A2 (0.49) | GPR119CYP1A2HPGDEPHX1USP2 | |
| SCHEMBL346826 | 0.83 | HPGD (0.47) | HRH3GPR119HPGDEPHX1USP2 | |
| SCHEMBL485035 | 0.81 | GPR119 (0.44) | HRH3GPR119HPGDEPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393803-A1 | SUBSTITUTED INDOLE COMPOUNDS AS BRADYKININ RECEPTOR 1 MODULATORS | Grünenthal GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| EP-2393812-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089127-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2010-08-12 | — | — | WO | disclosed |
| WO-2010089084-A1 | SUBSTITUTED INDOLE COMPOUNDS AS BRADYKININ RECEPTOR 1 MODULATORS | Grünenthal GmbH (DE) | 2010-08-12 | — | — | WO | disclosed |