Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ARG1 | P05089 | 4/20 | 0.36 |
| ▸ | ARG2 | P78540 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28705450 | 1.00 | GSR (0.53) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28707815 | 0.87 | GSR (0.50) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28707814 | 0.87 | GSR (0.50) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28698757 | 0.83 | GSR (0.54) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28698754 | 0.83 | GSR (0.54) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28421226 | 0.82 | GSR (0.53) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28421228 | 0.82 | GSR (0.53) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28424293 | 0.80 | GSR (0.50) | GSRTHRBARG1ARG2NOS2 | |
| Lysine SCHEMBL28424292 | 0.80 | GSR (0.50) | GSRTHRBARG1ARG2NOS2 | |
| Glycine SCHEMBL29260751 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110496645-B | Supported aminoalkyl ion liquid-metal catalyst and preparation and application thereof | 浙江工业大学 | 2022-03-18 | — | — | CN | disclosed |