Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28707990 | 1.00 | MAPT (0.56) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL28561983 | 0.88 | MAPT (0.57) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL28561984 | 0.88 | MAPT (0.57) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL29199765 | 0.86 | KDM4E (0.58) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL29199770 | 0.86 | KDM4E (0.58) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL27484962 | 0.82 | MAPT (0.59) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL27484963 | 0.82 | MAPT (0.59) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL28548649 | 0.81 | KDM4E (0.62) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL28548648 | 0.81 | KDM4E (0.62) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL28553170 | 0.79 | KDM4E (0.59) | MAPTKDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299420-B | Pentacyclic compounds as selective estrogen receptor down-regulators and uses thereof | 南京圣和药业股份有限公司 | 2021-10-15 | — | — | CN | disclosed |