Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 6/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388682 | 0.87 | IRAK1 (0.39) | BRAFIRAK1IRAK4RAF1ADORA2A | |
| SCHEMBL2873640 | 0.87 | IRAK1 (0.39) | BRAFIRAK1IRAK4RAF1MAPK3 | |
| SCHEMBL2870590 | 0.86 | IRAK1 (0.39) | BRAFIRAK1IRAK4RAF1MAPK3 | |
| SCHEMBL2879156 | 0.82 | BRAF (0.45) | BRAFIRAK1IRAK4RAF1MKNK1 | |
| SCHEMBL2972101 | 0.78 | IKBKB (0.50) | BRAFIRAK1IRAK4RAF1IKBKB | |
| SCHEMBL389292 | 0.77 | BRAF (0.46) | BRAFIRAK1IRAK4RAF1MAPK1 | |
| SCHEMBL393624 | 0.77 | BRAF (0.42) | BRAFIRAK1IRAK4RAF1MKNK1 | |
| SCHEMBL391684 | 0.77 | BRAF (0.41) | BRAFIRAK1IRAK4RAF1MKNK1 | |
| SCHEMBL1336964 | 0.77 | BRAF (0.41) | BRAFIRAK1IRAK4RAF1MKNK1 | |
| SCHEMBL391913 | 0.76 | BRAF (0.42) | BRAFIRAK1IRAK4RAF1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125794-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-10-20 | — | — | EP | disclosed |