Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.45 |
| ▸ | RAF1 | P04049 | 7/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | CHUK | O15111 | 2/20 | 0.37 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388891 | 0.85 | SCN9A (0.42) | BRAFRAF1IRAK1IRAK4SCN9A | |
| SCHEMBL2972101 | 0.85 | IKBKB (0.50) | BRAFRAF1IRAK1IRAK4IKBKB | |
| SCHEMBL391325 | 0.84 | BRAF (0.41) | BRAFRAF1IRAK1IRAK4SCN9A | |
| SCHEMBL2923633 | 0.84 | IRAK1 (0.40) | BRAFRAF1IRAK1IRAK4SCN9A | |
| SCHEMBL389292 | 0.84 | BRAF (0.46) | BRAFRAF1IRAK1IRAK4IKBKB | |
| SCHEMBL2878585 | 0.83 | IRAK1 (0.39) | BRAFRAF1IRAK1IRAK4SCN9A | |
| SCHEMBL392544 | 0.82 | BRAF (0.42) | BRAFRAF1IRAK1IRAK4IKBKB | |
| SCHEMBL391913 | 0.82 | BRAF (0.42) | BRAFRAF1IRAK1IRAK4IKBKB | |
| SCHEMBL2870826 | 0.82 | BRAF (0.40) | BRAFRAF1IRAK1IRAK4IKBKB | |
| SCHEMBL2984342 | 0.82 | BRAF (0.50) | BRAFRAF1IRAK1IRAK4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125794-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-10-20 | — | — | EP | disclosed |
| EP-2125793-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-09-01 | — | — | EP | disclosed |