Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.60 |
| ▸ | INSR | P06213 | 8/20 | 0.60 |
| ▸ | IGF1R | P08069 | 7/20 | 0.60 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28689797 | 0.95 | ALK (0.54) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL28703584 | 0.89 | ALK (0.51) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL28690880 | 0.86 | ALK (0.48) | ALKINSRIGF1RMAP4K1PTK2 | |
| SCHEMBL28703587 | 0.85 | PTK2 (0.45) | ALKINSRIGF1RMAP4K1PTK2 | |
| SCHEMBL28699319 | 0.85 | ALK (0.45) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL28689800 | 0.85 | ALK (0.45) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL28709120 | 0.84 | EGFR (0.57) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL28705404 | 0.83 | ALK (0.46) | ALKINSRIGF1RPTK2 | |
| SCHEMBL29449459 | 0.83 | ALK (0.44) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL31305007 | 0.79 | ALK (0.41) | ALKINSRIGF1RMAP4K1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181257-A | Pyridine compound, pharmaceutical composition containing pyridine compound, preparation method and application of pyridine compound | 四川科伦博泰生物医药股份有限公司 | 2022-03-15 | — | — | CN | disclosed |