Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
| ▸ | ULK1 | O75385 | 1/20 | 0.30 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.30 |
| ▸ | STK10 | O94804 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878752 | 0.93 | GRM5 (0.35) | GRM5FYNS1PR1KDM4EHTT | |
| SCHEMBL2878858 | 0.92 | KDM4E (0.39) | KDM4EHTTATMVCPALDH1A1 | |
| SCHEMBL2876910 | 0.86 | KDM4E (0.43) | GRM5FYNS1PR1KDM4EHTT | |
| SCHEMBL2874240 | 0.85 | KDM4E (0.38) | KDM4EHTTATMALDH1A1 | |
| SCHEMBL2874208 | 0.85 | KDM4E (0.38) | KDM4EHTTATMALDH1A1 | |
| SCHEMBL2877206 | 0.85 | KDM4E (0.38) | KDM4EHTTATMALDH1A1 | |
| SCHEMBL2879111 | 0.85 | IKBKB (0.37) | KDM4EHTTATMPOLBKCNH2 | |
| SCHEMBL2876663 | 0.83 | KDM4E (0.38) | KDM4EHTTATMALDH1A1 | |
| SCHEMBL2870899 | 0.83 | KDM4E (0.38) | KDM4EHTTATMCHEK1ALDH1A1 | |
| SCHEMBL2878751 | 0.83 | NR1I2 (0.39) | GRM5FYNS1PR1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569929-B9 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2011-09-14 | — | — | EP | claimed |
| EP-1569929-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2010-05-05 | — | — | EP | claimed |