Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 6/20 | 0.33 |
| ▸ | JAK1 | P23458 | 6/20 | 0.33 |
| ▸ | TYK2 | P29597 | 6/20 | 0.33 |
| ▸ | JAK3 | P52333 | 6/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609559 | 1.00 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28701328 | 1.00 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28701327 | 1.00 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL29608035 | 1.00 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL29609249 | 0.91 | MAP4K1 (0.56) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28709868 | 0.91 | MAP4K1 (0.56) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL29608109 | 0.91 | MAP4K1 (0.56) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28709869 | 0.91 | MAP4K1 (0.56) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28717476 | 0.91 | MAP4K1 (0.56) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL31246488 | 0.89 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-115028639-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114096536-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-02-25 | — | — | CN | disclosed |